snRNA 3'-end processing

Across TCGA cell cohorts, RNA activity of the snRNA 3'-end processing pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are USP10, INTS9, and ILF3, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, snRNA 3'-end processing activity versus USP10 in BLOOD_Myeloma (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	USP10 →	+1.230	+0.085	.002	.006	3	18
LIVER	INTS9 →	+1.029	+0.126	<.001	.001	3	18
BONE	ILF3 →	+1.273	+0.126	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	DHX9 →	+1.086	+0.083	<.001	<.001	3	17
BLOOD_Lymphoma	ZC3H18 →	+1.135	+0.075	<.001	<.001	3	17
LUNG_NSCLC_LUSC	EXOSC6 →	+0.977	+0.110	<.001	.003	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034472 vs USP10 — BLOOD_Myeloma

Explore this scatter interactively →