snRNA 3'-end processing

Across TCGA cell cohorts, RNA activity of the snRNA 3'-end processing pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM87B, NAP1L1, and ZFP36, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, snRNA 3'-end processing activity versus TMEM87B in BREAST (Pearson r = -0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TMEM87B →	-1.070	-1.258	<.001	<.001	3	6
BREAST	NAP1L1 →	+0.743	+1.036	.001	.003	3	6
LUNG_NSCLC_LUSC	ZFP36 →	-1.735	-1.908	.003	<.001	3	6
BLOOD_Lymphoma	PLEKHF2 →	-1.378	-1.011	.009	.007	3	6
BLOOD_Lymphoma	TMBIM4 →	-0.889	-1.210	.001	.001	3	6
BLOOD_Lymphoma	RNF103 →	-0.772	-1.078	.003	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034472 vs TMEM87B — BREAST

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