Microtubule anchoring

Across TCGA patient cohorts, RNA activity of the Microtubule anchoring pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACVRL1, MMP19, and MIR223HG, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Microtubule anchoring activity versus ACVRL1 in OV (Pearson r = -0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ACVRL1 →	-0.802	-0.738	<.001	.003	3	5
OV	MMP19 →	-1.406	-0.880	<.001	<.001	3	5
OV	MIR223HG →	-0.622	-0.641	<.001	.002	3	5
GBM	MEDAG →	-0.768	-0.619	.003	.001	3	5
GBM	FOSB →	-1.754	-0.692	<.001	.002	3	5
BRCA	SIRPB2 →	-0.421	-0.602	.007	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034453 vs ACVRL1 — OV

Explore this scatter interactively →