Microtubule anchoring

Across TCGA cell cohorts, RNA activity of the Microtubule anchoring pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DHX40, RNF216, and RAB11FIP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DHX40 grouped by Microtubule anchoring-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DHX40 →	-0.666	-0.878	.002	.007	3	4
URINARY_TRACT	RNF216 →	-0.999	-0.562	.001	.009	3	4
LUNG_NSCLC_LUSC	RAB11FIP2 →	-1.148	-0.378	.008	<.001	3	4
LUNG_NSCLC_LUSC	PRKAR1A →	-1.038	-0.307	.003	.005	3	4
STOMACH	GFUS →	+1.397	+0.346	<.001	<.001	3	3
STOMACH	SYTL1 →	+3.205	+0.381	.004	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DHX40 by Microtubule anchoring activity — LARGE_INTESTINE

Explore this box plot interactively →