Substrate adhesion-dependent cell spreading

Across TCGA patient cohorts, RNA activity of the Substrate adhesion-dependent cell spreading pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ISM1, SRPX, and CCN4, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Substrate adhesion-dependent cell spreading activity versus ISM1 in BRCA (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ISM1 →	+1.493	+0.248	<.001	<.001	3	3
BRCA	SRPX →	+1.552	+0.279	<.001	<.001	3	3
BRCA	CCN4 →	+1.015	+0.197	.009	.005	3	3
COAD	SFRP4 →	+2.803	+0.183	<.001	<.001	3	3
OV	ECM2 →	+1.196	+0.088	<.001	.003	3	3
OV	NKX3-2 →	+1.034	+0.105	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034446 vs ISM1 — BRCA

Explore this scatter interactively →