Substrate adhesion-dependent cell spreading

Across TCGA cell cohorts, RNA activity of the Substrate adhesion-dependent cell spreading pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DENND2C, SKP1, and CAMSAP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DENND2C grouped by Substrate adhesion-dependent cell spreading-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	DENND2C →	+0.335	+0.351	.008	.003	3	4
LUNG_NSCLC_LUAD	SKP1 →	+0.462	+0.617	.006	.006	2	5
LIVER	CAMSAP2 →	+1.136	+0.518	.003	<.001	3	4
BREAST	RTN4 →	+0.961	+0.335	<.001	<.001	3	4
SOFT_TISSUE	ANKRD10 →	-1.563	-0.337	.003	.001	3	4
LARGE_INTESTINE	CCDC102A →	+0.896	+1.115	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DENND2C by Substrate adhesion-dependent cell spreading activity — KIDNEY

Explore this box plot interactively →