Substrate adhesion-dependent cell spreading

Across TCGA cell cohorts, RNA activity of the Substrate adhesion-dependent cell spreading pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBP4, TLN1, and RAB1B, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RBP4 grouped by Substrate adhesion-dependent cell spreading-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	RBP4 →	+0.111	+0.071	.001	.007	3	7
LARGE_INTESTINE	TLN1 →	+0.310	+0.139	.003	.001	3	6
KIDNEY	RAB1B →	-0.235	-0.114	.003	<.001	3	6
LUNG_NSCLC_LUAD	WNT1 →	-0.115	-0.102	.002	.007	3	5
PANCREAS	TMEM97 →	-0.175	-0.194	.001	.001	2	6
BLOOD_Leukemia	ACAP1 →	+0.124	+0.063	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RBP4 by Substrate adhesion-dependent cell spreading activity — BREAST

Explore this box plot interactively →