Substrate adhesion-dependent cell spreading

Across TCGA cell cohorts, RNA activity of the Substrate adhesion-dependent cell spreading pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRAP1, TIMM8A, and LAMC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Substrate adhesion-dependent cell spreading activity versus TRAP1 in SOFT_TISSUE (Pearson r = -0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TRAP1 →	-0.797	-0.145	.005	.008	3	5
OVARY	TIMM8A →	-0.747	-0.314	.003	.001	3	5
BLOOD_Leukemia	LAMC1 →	+1.512	+0.577	.001	<.001	3	5
SOFT_TISSUE	MCRIP2 →	-1.273	-0.143	.002	.009	3	5
SKIN	HPCAL4 →	-0.391	-0.444	<.001	.006	3	4
URINARY_TRACT	DDX55 →	-0.787	-0.628	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034446 vs TRAP1 — SOFT_TISSUE

Explore this scatter interactively →