Lipid oxidation

Across TCGA patient cohorts, RNA activity of the Lipid oxidation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DLGAP5, KIF23, and PBK, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lipid oxidation activity versus DLGAP5 in BRCA (Pearson r = -0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DLGAP5 →	-0.834	-0.198	<.001	<.001	3	6
UCEC	KIF23 →	-0.693	-0.140	.004	<.001	3	6
COAD	PBK →	-0.943	-0.227	.001	<.001	3	6
BRCA	CDCA2 →	-0.924	-0.189	<.001	<.001	3	6
BRCA	UBE2S →	-1.254	-0.255	<.001	<.001	3	6
UCEC	KIF15 →	-0.877	-0.119	.002	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034440 vs DLGAP5 — BRCA

Explore this scatter interactively →