Lipid oxidation

Across TCGA cell cohorts, RNA activity of the Lipid oxidation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC44A3, MMEL1, and LNX1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lipid oxidation activity versus SLC44A3 in LARGE_INTESTINE (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SLC44A3 →	+1.976	+0.253	.005	.001	3	8
PANCREAS	MMEL1 →	+2.588	+0.337	.001	.002	3	8
BREAST	LNX1 →	+1.421	+0.297	<.001	<.001	3	8
LIVER	FAM216A →	-1.380	-0.169	.006	.004	3	7
BLOOD_Lymphoma	TM9SF2 →	+0.874	+0.133	.004	.009	3	6
LARGE_INTESTINE	SAAL1 →	-0.813	-0.299	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034440 vs SLC44A3 — LARGE_INTESTINE

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