Response to fluid shear stress

Across TCGA patient cohorts, RNA activity of the Response to fluid shear stress pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RRAS, ENOX1, and CALHM5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to fluid shear stress activity versus RRAS in LSCC (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RRAS →	+0.462	+0.582	<.001	.001	3	6
BRCA	ENOX1 →	+0.687	+0.499	.001	.001	3	5
BRCA	CALHM5 →	+0.527	+0.457	.001	.002	3	5
LUAD	LIPT2 →	-0.248	-0.291	.004	.001	3	5
LUAD	AMIGO1 →	-0.578	-0.288	.003	.008	3	5
PDAC	LRRC15 →	+0.915	+0.322	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034405 vs RRAS — LSCC

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