Nucleobase-containing small molecule biosynthetic process

Across TCGA patient cohorts, RNA activity of the Nucleobase-containing small molecule biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CORO2B, SNX9, and ADPRH, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleobase-containing small molecule biosynthetic process activity versus CORO2B in BRCA (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CORO2B →	+0.540	+0.034	<.001	<.001	3	7
OV	SNX9 →	+0.481	+0.055	<.001	<.001	3	6
OV	ADPRH →	+0.471	+0.052	<.001	<.001	2	7
UCEC	GPC6 →	+0.426	+0.032	.001	.007	3	6
OV	NID2 →	+0.594	+0.056	<.001	<.001	3	6
OV	PRKG1 →	+0.722	+0.057	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034404 vs CORO2B — BRCA

Explore this scatter interactively →