Nucleobase-containing small molecule biosynthetic process

Across TCGA cell cohorts, RNA activity of the Nucleobase-containing small molecule biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS2, TMEM97, and RPUSD4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleobase-containing small molecule biosynthetic process activity versus RPS2 in CNS (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	RPS2 →	+0.729	+1.013	<.001	<.001	3	6
BLOOD_Leukemia	TMEM97 →	+0.810	+0.273	<.001	<.001	3	6
CNS	RPUSD4 →	+0.651	+0.865	.001	.004	3	5
PANCREAS	WDR75 →	+1.030	+1.150	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	MRPL10 →	+0.774	+1.542	.007	.002	3	5
OVARY	SAFB2 →	+1.093	+1.300	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034404 vs RPS2 — CNS

Explore this scatter interactively →