Telomere tethering at nuclear periphery

Across TCGA patient cohorts, RNA activity of the Telomere tethering at nuclear periphery pathway is significantly associated with the RNA expression of multiple genes, with the KICH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRYBG3, NOMO2, and STAU1, each associated with the pathway in up to 30 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Telomere tethering at nuclear periphery activity versus CRYBG3 in KICH (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KICH	CRYBG3 →	+1.466	+0.054	<.001	<.001	3	30
THYM	NOMO2 →	+1.314	+0.111	<.001	<.001	3	30
KICH	STAU1 →	+0.725	+0.057	<.001	<.001	3	29
UCS	EIF4HP1 →	+1.005	+0.097	<.001	<.001	3	29
THYM	SEC24C →	+1.919	+0.092	<.001	<.001	3	29
PCPG	PLEKHM3 →	+1.181	+0.086	<.001	<.001	3	29

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034398 vs CRYBG3 — KICH

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