Telomere tethering at nuclear periphery

Across TCGA patient cohorts, RNA activity of the Telomere tethering at nuclear periphery pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PURB, PURB_S304, and STAT1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Telomere tethering at nuclear periphery activity versus PURB in HNSC (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PURB →	+0.389	+0.049	<.001	.008	3	6
HNSC	PURB_S304 →	+0.507	+0.067	<.001	<.001	3	6
CCRCC	STAT1 →	-0.584	-0.060	<.001	.001	3	5
PDAC	UBE2L6 →	-0.432	-0.054	<.001	<.001	3	5
HNSC	NUDCD3 →	+0.313	+0.069	.001	.002	3	5
LSCC	FOXK1 →	+0.222	+0.039	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034398 vs PURB — HNSC

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