Telomere tethering at nuclear periphery

Across TCGA cell cohorts, RNA activity of the Telomere tethering at nuclear periphery pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM83E, EFHD1, and MRPL37, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FAM83E grouped by Telomere tethering at nuclear periphery-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	FAM83E →	+0.175	+0.333	.004	<.001	3	2
SOFT_TISSUE	EFHD1 →	+2.460	+0.400	.009	.003	3	2
SOFT_TISSUE	MRPL37 →	+0.658	+0.394	.006	.001	3	2
SOFT_TISSUE	CCDC121 →	+1.060	+0.482	<.001	<.001	3	2
LUNG_SCLC	KIF18A →	-1.479	-0.410	.001	<.001	3	2
LUNG_SCLC	TSG101 →	-0.829	-0.310	.003	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FAM83E by Telomere tethering at nuclear periphery activity — SOFT_TISSUE

Explore this box plot interactively →