Telomere localization

Across TCGA patient cohorts, RNA activity of the Telomere localization pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL7, TAP1, and ITGA1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Telomere localization activity versus RPL7 in BRCA (Pearson r = -0.06).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RPL7 →	-0.264	-0.037	<.001	<.001	3	5
LSCC	TAP1 →	-0.536	-0.048	<.001	<.001	3	5
HNSC	ITGA1 →	+0.331	+0.081	.001	.003	3	5
LSCC	RGS14_S288 →	-0.656	-0.044	<.001	<.001	3	5
LUAD	IRS2_S1100 →	+0.754	+0.034	.003	.002	3	5
LUAD	PFN2 →	+0.402	+0.043	.003	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034397 vs RPL7 — BRCA

Explore this scatter interactively →