Telomere localization

Across TCGA patient cohorts, RNA activity of the Telomere localization pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RINT1, PBK, and DNAJC2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Telomere localization activity versus RINT1 in HNSC (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RINT1 →	+0.633	+0.501	.002	.007	3	5
HNSC	PBK →	+0.921	+0.619	<.001	<.001	3	5
LSCC	DNAJC2 →	+0.537	+0.436	<.001	.007	3	4
LSCC	SNRPE →	+0.651	+0.415	<.001	<.001	3	4
BRCA	SFXN4 →	+0.426	+0.443	<.001	.002	3	4
LSCC	SPAG5 →	+0.722	+0.341	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034397 vs RINT1 — HNSC

Explore this scatter interactively →