Protein localization to cell surface

Across TCGA patient cohorts, RNA activity of the Protein localization to cell surface pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ACTN1, VCL_S795, and GSN, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to cell surface activity versus ACTN1 in BRCA (Pearson r = 0.54).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ACTN1 →	+0.469	+0.358	<.001	<.001	3	8
HNSC	VCL_S795 →	+0.654	+0.213	<.001	<.001	3	8
UCEC	GSN →	+0.622	+0.472	<.001	.003	3	8
UCEC	PRKG1 →	+1.139	+0.492	<.001	.001	3	8
BRCA	SERPINF1 →	+0.910	+0.343	<.001	<.001	3	8
BRCA	PCOLCE →	+0.710	+0.402	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034394 vs ACTN1 — BRCA

Explore this scatter interactively →