Protein localization to cell surface

Across TCGA cell cohorts, RNA activity of the Protein localization to cell surface pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANXA2, FLNA, and FRMD5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to cell surface activity versus ANXA2 in BREAST (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ANXA2 →	+1.585	+0.304	.006	.001	3	6
BREAST	FLNA →	+1.612	+0.247	.001	.001	3	6
PANCREAS	FRMD5 →	+1.327	+0.300	.001	<.001	3	6
BLOOD_Leukemia	VCL →	+1.698	+0.400	<.001	.001	3	5
BONE	PRDM1 →	+0.989	+0.257	.001	<.001	3	5
LUNG_NSCLC_LUAD	PPL →	+1.812	+0.150	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034394 vs ANXA2 — BREAST

Explore this scatter interactively →