Positive regulation of smooth muscle cell apoptotic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of smooth muscle cell apoptotic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TPX2_S738, GMPPB, and IGF2BP2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of smooth muscle cell apoptotic process activity versus TPX2_S738 in BRCA (Pearson r = 0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TPX2_S738 →	+1.305	+0.098	<.001	<.001	3	8
BRCA	GMPPB →	-0.272	-0.070	<.001	<.001	3	7
BRCA	IGF2BP2 →	+1.014	+0.089	<.001	<.001	3	7
BRCA	MCM6_S762 →	+1.169	+0.094	<.001	<.001	3	7
BRCA	WRNIP1 →	+0.324	+0.068	.001	.003	3	7
BRCA	REXO4 →	+0.619	+0.101	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034393 vs TPX2_S738 — BRCA

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