Positive regulation of smooth muscle cell apoptotic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of smooth muscle cell apoptotic process pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MDM2, HAPLN1, and NOL8, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MDM2 grouped by Positive regulation of smooth muscle cell apoptotic process-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	MDM2 →	-0.474	-0.132	<.001	.007	3	5
BLOOD_Leukemia	HAPLN1 →	+0.166	+0.169	<.001	<.001	3	5
LUNG_SCLC	NOL8 →	-0.401	-0.156	<.001	<.001	3	5
KIDNEY	OTUB1 →	-0.365	-0.139	.001	<.001	3	4
SOFT_TISSUE	H2BC4 →	-0.329	-0.143	<.001	<.001	3	4
OVARY	STX3 →	-0.233	-0.142	.006	.004	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MDM2 by Positive regulation of smooth muscle cell apoptotic process activity — SOFT_TISSUE

Explore this box plot interactively →