Positive regulation of smooth muscle cell apoptotic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of smooth muscle cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are THUMPD2, SYTL4, and LIME1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of smooth muscle cell apoptotic process activity versus THUMPD2 in PANCREAS (Pearson r = -0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	THUMPD2 →	-0.662	-0.243	.001	.003	3	4
LUNG_NSCLC_LUSC	SYTL4 →	+2.061	+0.188	.009	.001	3	4
BLOOD_Leukemia	LIME1 →	-1.382	-0.500	<.001	.002	3	3
BLOOD_Myeloma	SOD2 →	+0.897	+0.366	<.001	.003	3	3
BLOOD_Myeloma	CAPN10 →	-0.524	-0.281	.002	.005	3	3
LUNG_SCLC	CERS1 →	+1.457	+0.179	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034393 vs THUMPD2 — PANCREAS

Explore this scatter interactively →