Lipid droplet organization

Across TCGA patient cohorts, RNA activity of the Lipid droplet organization pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NUP50, RPL31_S98, and SEC63, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lipid droplet organization activity versus NUP50 in GBM (Pearson r = -0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NUP50 →	-0.219	-0.036	<.001	<.001	3	7
BRCA	RPL31_S98 →	-1.579	-0.060	.001	.006	3	6
CCRCC	SEC63 →	-0.210	-0.027	.001	.001	3	6
HNSC	SELENOK →	-0.321	-0.059	.007	.003	3	6
GBM	EIF3A →	-0.153	-0.039	<.001	.001	3	6
BRCA	USP10 →	-0.336	-0.043	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034389 vs NUP50 — GBM

Explore this scatter interactively →