Lipid droplet organization

Across TCGA patient cohorts, RNA activity of the Lipid droplet organization pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H4C3, PTGIS, and TAF5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lipid droplet organization activity versus H4C3 in GBM (Pearson r = -0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	H4C3 →	-1.027	-0.156	<.001	<.001	3	5
CCRCC	PTGIS →	-0.839	-0.127	.004	.003	3	4
BRCA	TAF5 →	-0.333	-0.169	.009	.003	3	4
GBM	MR1 →	+0.460	+0.131	.003	<.001	3	4
GBM	HDAC2 →	-0.368	-0.080	.001	.001	3	4
BRCA	GALNT18 →	-0.756	-0.205	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034389 vs H4C3 — GBM

Explore this scatter interactively →