Lipid droplet organization

Across TCGA cell cohorts, RNA activity of the Lipid droplet organization pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZYX, IL31RA, and C11orf68, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZYX grouped by Lipid droplet organization-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	ZYX →	-1.360	-1.514	.007	.005	3	4
BONE	IL31RA →	-3.494	-1.597	<.001	.004	3	4
URINARY_TRACT	C11orf68 →	-1.536	-1.628	.001	<.001	2	5
LUNG_NSCLC_LUSC	DNTTIP1 →	-1.398	-1.440	.001	<.001	3	4
BONE	MSANTD3 →	-1.820	-2.184	<.001	<.001	3	4
LUNG_NSCLC_LUSC	IGFBP7 →	-5.298	-1.401	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZYX by Lipid droplet organization activity — URINARY_TRACT

Explore this box plot interactively →