Lipid droplet organization

Across TCGA cell cohorts, RNA activity of the Lipid droplet organization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NEDD4, TRIM45, and FKBP10, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lipid droplet organization activity versus NEDD4 in BLOOD_Leukemia (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NEDD4 →	+1.339	+0.128	.001	.001	3	6
BLOOD_Lymphoma	TRIM45 →	+1.456	+0.252	<.001	.002	3	5
BLOOD_Leukemia	FKBP10 →	+2.190	+0.169	<.001	<.001	3	5
BLOOD_Leukemia	AIDA →	+0.554	+0.088	.002	.003	3	5
OVARY	TADA3 →	+0.977	+0.271	.001	.001	3	5
LUNG_SCLC	DEDD2 →	-0.623	-0.126	.006	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034389 vs NEDD4 — BLOOD_Leukemia

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