Lipid droplet organization

Across TCGA cell cohorts, RNA activity of the Lipid droplet organization pathway is significantly associated with the protein abundance of multiple proteins, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EEF1G, CDC37, and PFDN6, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lipid droplet organization activity versus EEF1G in LARGE_INTESTINE (Pearson r = 0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	EEF1G →	+1.187	+0.198	.002	.004	3	13
OESOPHAGUS	CDC37 →	+1.212	+0.256	.001	.009	3	12
OVARY	PFDN6 →	+1.822	+0.325	<.001	<.001	3	12
LARGE_INTESTINE	TUBB →	+2.029	+0.283	<.001	<.001	3	12
URINARY_TRACT	COPE →	+1.395	+0.263	.008	.007	2	13
OVARY	EIF3A →	+1.386	+0.357	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034389 vs EEF1G — LARGE_INTESTINE

Explore this scatter interactively →