High-density lipoprotein particle assembly

Across TCGA patient cohorts, RNA activity of the High-density lipoprotein particle assembly pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLC9A3R1_S280, PGLS, and TMEM181, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, High-density lipoprotein particle assembly activity versus SLC9A3R1_S280 in BRCA (Pearson r = -0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SLC9A3R1_S280 →	-0.739	-0.041	.001	<.001	3	5
COAD	PGLS →	+0.179	+0.026	.001	.003	3	5
LUAD	TMEM181 →	-0.372	-0.041	.005	.003	3	4
OV	CLPX →	-0.221	-0.055	.006	.004	3	4
LUAD	RRP7A →	-0.182	-0.041	.004	.001	3	4
COAD	RFXANK →	+0.635	+0.142	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034380 vs SLC9A3R1_S280 — BRCA

Explore this scatter interactively →