High-density lipoprotein particle assembly

Across TCGA cell cohorts, RNA activity of the High-density lipoprotein particle assembly pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CPLX1, NDUFS2, and COA8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CPLX1 grouped by High-density lipoprotein particle assembly-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CPLX1 →	+1.432	+1.621	<.001	<.001	3	4
CNS	NDUFS2 →	+0.236	+0.727	.008	.006	3	4
CNS	COA8 →	-0.806	-1.008	.001	.005	3	4
UPPER_AERODIGESTIVE_TRACT	TRMT9B →	+0.208	+1.101	.008	.002	3	4
LUNG_NSCLC_LUAD	SYNJ2 →	-0.886	-0.773	<.001	<.001	3	4
BREAST	RPRD1B →	+0.486	+0.643	.006	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CPLX1 by High-density lipoprotein particle assembly activity — OVARY

Explore this box plot interactively →