High-density lipoprotein particle assembly

Across TCGA cell cohorts, RNA activity of the High-density lipoprotein particle assembly pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OTUD1, USP51, and INTS13, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, High-density lipoprotein particle assembly activity versus OTUD1 in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	OTUD1 →	-1.330	-1.581	.004	<.001	2	4
SKIN	USP51 →	+0.783	+1.378	.007	<.001	3	3
BLOOD_Leukemia	INTS13 →	+0.323	+1.353	.008	<.001	2	4
SOFT_TISSUE	SUPT4H1 →	-0.823	-1.611	.002	<.001	3	3
LARGE_INTESTINE	ADO →	-0.503	-1.357	.003	<.001	3	3
OVARY	SP4 →	+0.923	+1.384	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034380 vs OTUD1 — UPPER_AERODIGESTIVE_TRACT

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