Regulation of glial cell apoptotic process

Across TCGA patient cohorts, RNA activity of the Regulation of glial cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SCN7A, AKAP12, and SGCA, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of glial cell apoptotic process activity versus SCN7A in UCEC (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SCN7A →	+1.189	+0.666	<.001	<.001	3	9
LUAD	AKAP12 →	+1.114	+0.657	<.001	.005	3	9
LSCC	SGCA →	+0.807	+0.929	<.001	<.001	3	8
UCEC	LMOD1 →	+1.435	+0.702	<.001	<.001	3	8
LSCC	FHL5 →	+1.008	+0.788	<.001	.001	3	8
HNSC	CDO1 →	+0.963	+0.932	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034350 vs SCN7A — UCEC

Explore this scatter interactively →