Regulation of glial cell apoptotic process

Across TCGA cell cohorts, RNA activity of the Regulation of glial cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PGBD5, NIPAL2, and FGFR1OP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PGBD5 grouped by Regulation of glial cell apoptotic process-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	PGBD5 →	+1.714	+0.982	.001	.008	3	5
BLOOD_Leukemia	NIPAL2 →	-2.277	-1.504	<.001	<.001	3	4
OVARY	FGFR1OP2 →	-1.047	-1.326	.006	<.001	3	4
LUNG_NSCLC_LUAD	SNX6 →	-0.861	-0.789	.001	.001	3	4
BLOOD_Myeloma	NSMAF →	-1.104	-1.637	.002	.003	2	4
BLOOD_Leukemia	BBC3 →	-1.728	-1.360	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PGBD5 by Regulation of glial cell apoptotic process activity — LIVER

Explore this box plot interactively →