Regulation of glial cell apoptotic process

Across TCGA cell cohorts, RNA activity of the Regulation of glial cell apoptotic process pathway is significantly associated with the shRNA dependency of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VAMP4, CCNB2, and GLP2R, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VAMP4 grouped by Regulation of glial cell apoptotic process-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	VAMP4 →	+0.133	+0.947	.005	.005	3	4
SOFT_TISSUE	CCNB2 →	-0.436	-1.815	.004	<.001	3	4
SOFT_TISSUE	GLP2R →	+0.363	+1.619	<.001	<.001	3	4
SKIN	ATF6B →	+0.144	+0.984	.004	.002	3	3
BREAST	FEZ1 →	+0.196	+0.784	<.001	<.001	3	3
BREAST	CCDC3 →	-0.147	-0.574	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VAMP4 by Regulation of glial cell apoptotic process activity — OESOPHAGUS

Explore this box plot interactively →