Regulation of glial cell apoptotic process

Across TCGA cell cohorts, RNA activity of the Regulation of glial cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MARCHF9, SLC18B1, and DOCK10, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of glial cell apoptotic process activity versus MARCHF9 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	MARCHF9 →	+0.748	+0.846	.008	.005	3	5
OVARY	SLC18B1 →	-1.092	-0.941	.001	.006	3	4
SOFT_TISSUE	DOCK10 →	+3.655	+1.378	.007	.002	3	4
LIVER	GCHFR →	-3.780	-1.292	.003	.002	3	4
LIVER	FRRS1 →	-2.128	-0.962	<.001	.006	3	4
LARGE_INTESTINE	NR3C1 →	+1.147	+0.877	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034350 vs MARCHF9 — UPPER_AERODIGESTIVE_TRACT

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