Glial cell apoptotic process

Across TCGA cell cohorts, RNA activity of the Glial cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DDB2, MDM2, and PHLDA3, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DDB2 grouped by Glial cell apoptotic process-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	DDB2 →	-1.787	-1.289	<.001	.006	3	10
SKIN	MDM2 →	-1.591	-1.125	<.001	<.001	3	8
LUNG_SCLC	PHLDA3 →	-2.472	-1.305	<.001	<.001	3	8
CNS	ZMAT3 →	-1.344	-1.333	<.001	<.001	3	7
SOFT_TISSUE	SESN1 →	-1.633	-1.377	.001	.007	2	8
OVARY	CDKN1A →	-2.599	-1.282	.001	.001	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DDB2 by Glial cell apoptotic process activity — SOFT_TISSUE

Explore this box plot interactively →