Response to type II interferon

Across TCGA patient cohorts, RNA activity of the Response to type II interferon pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1, RIN3, and SAMSN1_S23, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to type II interferon activity versus RCSD1 in GBM (Pearson r = 0.77).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RCSD1 →	+0.623	+0.085	<.001	<.001	3	10
GBM	RIN3 →	+0.476	+0.063	<.001	<.001	3	10
BRCA	SAMSN1_S23 →	+1.127	+0.053	<.001	<.001	3	10
GBM	SASH3 →	+0.599	+0.095	<.001	<.001	3	10
GBM	SKAP2 →	+0.822	+0.085	<.001	<.001	3	10
LSCC	SPN_S355 →	+0.926	+0.083	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034341 vs RCSD1 — GBM

Explore this scatter interactively →