Response to type II interferon

Across TCGA patient cohorts, RNA activity of the Response to type II interferon pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LILRB1, CD4, and CHST11, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to type II interferon activity versus LILRB1 in HNSC (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	LILRB1 →	+0.790	+0.176	<.001	.005	3	8
LUAD	CD4 →	+0.533	+0.110	<.001	<.001	3	8
LSCC	CHST11 →	+0.901	+0.338	.003	<.001	3	8
LUAD	FCGR2C →	+1.029	+0.166	<.001	<.001	3	8
BRCA	ARHGAP9 →	+0.623	+0.227	.005	.002	3	7
UCEC	ADGRE2 →	+0.613	+0.133	.001	.003	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034341 vs LILRB1 — HNSC

Explore this scatter interactively →