Response to type II interferon

Across TCGA cell cohorts, RNA activity of the Response to type II interferon pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSMB8, SLC12A4, and MXRA7, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PSMB8 grouped by Response to type II interferon-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PSMB8 →	+2.233	+0.141	.001	.005	2	6
OESOPHAGUS	SLC12A4 →	+1.736	+0.241	.002	.008	3	4
OESOPHAGUS	MXRA7 →	+2.001	+0.193	.001	.008	3	4
OESOPHAGUS	FLNA →	+1.168	+0.162	.003	.003	3	4
UPPER_AERODIGESTIVE_TRACT	TBC1D2B →	+0.858	+0.376	.004	.006	3	4
BREAST	PTGFR →	+0.896	+0.133	.006	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PSMB8 by Response to type II interferon activity — BREAST

Explore this box plot interactively →