Response to type II interferon

Across TCGA cell cohorts, RNA activity of the Response to type II interferon pathway is significantly associated with the protein abundance of multiple proteins, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PSMB4, PSMA1, and PSMB1, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to type II interferon activity versus PSMB4 in URINARY_TRACT (Pearson r = 0.82).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PSMB4 →	+1.850	+0.543	<.001	<.001	3	18
URINARY_TRACT	PSMA1 →	+1.724	+0.629	<.001	<.001	3	17
URINARY_TRACT	PSMB1 →	+1.301	+0.396	<.001	<.001	3	17
LUNG_NSCLC_LUSC	PSMB3 →	+1.374	+0.493	.008	.003	3	17
URINARY_TRACT	PSMA6 →	+1.955	+0.576	.001	.002	3	17
URINARY_TRACT	PSMA2 →	+1.545	+0.527	<.001	.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034341 vs PSMB4 — URINARY_TRACT

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