Adherens junction maintenance

Across TCGA patient cohorts, RNA activity of the Adherens junction maintenance pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NDRG1, SDC1, and DHRS3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adherens junction maintenance activity versus NDRG1 in BRCA (Pearson r = 0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NDRG1 →	+0.456	+0.035	.004	.008	3	6
OV	SDC1 →	+0.709	+0.063	<.001	.002	3	5
HNSC	DHRS3 →	+0.540	+0.083	<.001	<.001	3	5
COAD	RAI14 →	+0.301	+0.037	.002	.003	3	5
LSCC	HSPA13 →	-0.337	-0.045	.001	.002	3	5
GBM	F11R →	+0.283	+0.043	.007	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034334 vs NDRG1 — BRCA

Explore this scatter interactively →