Adherens junction maintenance

Across TCGA cell cohorts, RNA activity of the Adherens junction maintenance pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EXTL2, SLC23A3, and SNAP25, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EXTL2 grouped by Adherens junction maintenance-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	EXTL2 →	+0.318	+0.271	<.001	<.001	3	5
PANCREAS	SLC23A3 →	+0.147	+0.149	<.001	.002	3	5
BREAST	SNAP25 →	-0.156	-0.109	.004	<.001	3	4
LUNG_NSCLC_LUSC	INS →	-0.244	-0.208	.005	.004	3	4
LUNG_NSCLC_LUAD	FERD3L →	-0.082	-0.073	.002	.008	3	4
OVARY	MYH9 →	+0.215	+0.103	.004	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EXTL2 by Adherens junction maintenance activity — LIVER

Explore this box plot interactively →