Adherens junction maintenance

Across TCGA cell cohorts, RNA activity of the Adherens junction maintenance pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BST1, TRMT10A, and VEPH1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adherens junction maintenance activity versus BST1 in LUNG_SCLC (Pearson r = -0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	BST1 →	-0.514	-1.194	<.001	<.001	3	3
LUNG_SCLC	TRMT10A →	-0.820	-1.017	<.001	.003	3	3
LUNG_SCLC	VEPH1 →	+0.980	+0.870	.003	.002	3	3
BREAST	CHORDC1 →	-0.947	-0.893	.003	.002	3	3
BLOOD_Leukemia	SATB1 →	-2.894	-1.105	.003	.003	3	3
BLOOD_Myeloma	SLC5A6 →	-1.035	-1.860	.008	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034334 vs BST1 — LUNG_SCLC

Explore this scatter interactively →