Adherens junction assembly

Across TCGA patient cohorts, RNA activity of the Adherens junction assembly pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EDNRA, MSRB3, and PRKG1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adherens junction assembly activity versus EDNRA in BRCA (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	EDNRA →	+0.935	+0.259	<.001	.001	3	8
OV	MSRB3 →	+0.926	+0.822	.003	<.001	2	9
UCEC	PRKG1 →	+1.090	+0.439	<.001	.006	3	8
BRCA	ACTA2 →	+1.131	+0.247	<.001	.002	3	8
BRCA	TAGLN →	+1.033	+0.303	<.001	.004	2	9
UCEC	LMOD1 →	+1.460	+0.416	<.001	.009	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034333 vs EDNRA — BRCA

Explore this scatter interactively →