Adherens junction assembly

Across TCGA cell cohorts, RNA activity of the Adherens junction assembly pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AMN, NMD3, and SQLE, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adherens junction assembly activity versus AMN in STOMACH (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	AMN →	+3.179	+0.289	.002	.008	3	5
OVARY	NMD3 →	+0.839	+0.253	.002	.002	3	5
LIVER	SQLE →	+1.271	+0.276	<.001	<.001	3	5
LUNG_NSCLC_LUAD	SENP2 →	+0.768	+0.260	<.001	<.001	3	5
LUNG_NSCLC_LUAD	MMAB →	+1.155	+0.321	<.001	.003	3	5
SOFT_TISSUE	SLC38A10 →	+0.813	+0.333	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034333 vs AMN — STOMACH

Explore this scatter interactively →