Cell junction maintenance

Across TCGA patient cohorts, RNA activity of the Cell junction maintenance pathway is significantly associated with the RNA expression of multiple genes, with the SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLCN6, ZNF337, and PLEKHH2, each associated with the pathway in up to 28 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell junction maintenance activity versus CLCN6 in SCLC (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	CLCN6 →	+0.979	+0.052	<.001	<.001	3	28
DLBC	ZNF337 →	+0.872	+0.053	<.001	<.001	3	28
KICH	PLEKHH2 →	+1.514	+0.019	<.001	.001	3	28
DLBC	CHD2 →	+0.975	+0.047	<.001	<.001	3	28
SCLC	CIC →	+1.251	+0.098	<.001	<.001	3	28
SCLC	ABCA2 →	+1.840	+0.103	<.001	<.001	3	27

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034331 vs CLCN6 — SCLC

Explore this scatter interactively →