Cell junction maintenance

Across TCGA patient cohorts, RNA activity of the Cell junction maintenance pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LAT_S224, CD4, and CD48, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell junction maintenance activity versus LAT_S224 in HNSC (Pearson r = -0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	LAT_S224 →	-0.582	-0.040	.001	.003	3	5
HNSC	CD4 →	-0.446	-0.038	<.001	.004	3	4
HNSC	CD48 →	-0.693	-0.049	<.001	<.001	3	4
BRCA	IKZF1_S63 →	-0.678	-0.024	.007	.005	2	5
HNSC	PTPRC →	-0.520	-0.039	<.001	<.001	3	4
HNSC	CARMIL2_S1381 →	-0.629	-0.033	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034331 vs LAT_S224 — HNSC

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