Cell junction maintenance

Across TCGA cell cohorts, RNA activity of the Cell junction maintenance pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBC1D9, AVPR1A, and LSM6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TBC1D9 grouped by Cell junction maintenance-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	TBC1D9 →	-0.546	-1.868	.001	<.001	3	3
LUNG_SCLC	AVPR1A →	-0.157	-1.136	.009	.005	3	3
BONE	LSM6 →	-0.479	-1.786	<.001	<.001	3	3
LUNG_NSCLC_LUAD	ARPC1B →	+0.193	+0.932	<.001	<.001	2	4
LUNG_NSCLC_LUAD	DOCK1 →	+0.131	+1.028	.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	KCNJ15 →	-0.092	-0.527	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TBC1D9 by Cell junction maintenance activity — BLOOD_Lymphoma

Explore this box plot interactively →