Negative regulation of Arp2/3 complex-mediated actin nucleation

Across TCGA patient cohorts, RNA activity of the Negative regulation of Arp2/3 complex-mediated actin nucleation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PICK1, DESI1, and RNF25, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of Arp2/3 complex-mediated actin nucleation activity versus PICK1 in GBM (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PICK1 →	+0.410	+0.086	.001	.001	3	5
GBM	DESI1 →	+0.354	+0.089	<.001	<.001	3	5
LUAD	RNF25 →	-0.147	-0.059	<.001	<.001	3	4
GBM	IMP4 →	-0.187	-0.068	<.001	<.001	3	4
GBM	PMM1 →	+0.392	+0.079	<.001	<.001	3	4
GBM	EMC8 →	-0.160	-0.064	.006	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034316 vs PICK1 — GBM

Explore this scatter interactively →