Negative regulation of Arp2/3 complex-mediated actin nucleation

Across TCGA patient cohorts, RNA activity of the Negative regulation of Arp2/3 complex-mediated actin nucleation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC37A1, FBXL15, and BEX5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of Arp2/3 complex-mediated actin nucleation activity versus SLC37A1 in LSCC (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SLC37A1 →	+0.708	+0.146	<.001	<.001	3	5
GBM	FBXL15 →	+0.358	+0.173	.003	<.001	3	4
GBM	BEX5 →	+1.040	+0.181	<.001	<.001	3	4
LUAD	STARD10 →	+0.600	+0.113	<.001	<.001	3	4
CCRCC	MRAP →	-0.235	-0.129	.004	.001	3	4
CCRCC	TMEM125 →	+1.059	+0.136	.007	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034316 vs SLC37A1 — LSCC

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